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C8 Study Publications

This list of published articles is complete as of November 2013. Some more articles from the past C8 Science Panel research are still expected to follow as review and publication takes some time.

Associations Between Serum Perfluoroalkyl Acids and LINE-1 DNA Methylation.

Watkins DJ, Wellenius GA, Butler RA, Bartell SM, Fletcher T, Kelsey KT.
Environment Int. 2014 Feb;63:71-76.
Full text available at: http://dx.doi.org/10.1016/j.envint.2013.10.018

Influenza vaccine response in adults exposed to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS).

Looker C, Luster MI, Calafat AM, Johnson VJ, Burleson GR, Burleson FG, Fletcher T.
Toxicol Sci. Published online: Nov 27, 2013.
Full text available at: http://toxsci.oxfordjournals.org/content/early/2013/11/25/toxsci.kft269

Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers Among Adults Living Near a Chemical Plant.

Barry V, Winquist A, Steenland K.
Environ Health Perspect. 2013 Nov;121(11):1313-18.
Full text available at: http://ehp.niehs.nih.gov/1306615/

Serum Perfluorooctanoic Acid and Perfluorooctane Sulfonate Concentrations in Relation to Birth Outcomes in the Mid-Ohio Valley, 2005-2010.

Darrow LA, Stein CR, Steenland K.
Environ Health Perspect. 2013 Oct;121(10):1207-13.
Full text available at: http://ehp.niehs.nih.gov/1206372/

Design, methods, and population for a study of PFOA health effects among highly exposed Mid-Ohio Valley community residents and workers.

Winquist A, Lally C, Shin HM, Steenland K.
Environ Health Perspect. 2013 Aug;121(8):893-9.
Full text available at: http://ehp.niehs.nih.gov/1206450/

Ulcerative colitis and perfluorooctanoic acid (PFOA) in a highly exposed population of community residents and workers in the Mid-Ohio Valley.

Steenland K, Zhao L, Winquist A, Parks C.
Environ Health Perspect. 2013 Aug;121(8):900-5.
Full text available at: http://ehp.niehs.nih.gov/1206449/

Assessing the Spatial Distribution of Perfluorooctanoic Acid Exposure via Public Drinking Water Pipes Using Geographic Information Systems.

Vieira V, Hoffman K, Fletcher T.
Environ Health Toxicol. 2013 Aug 30
Full text available at: http://e-eht.org/DOIx.php?id=10.5620/eht.2013.28.e2013009

Reductions in serum lipids with a 4-year decline in serum perfluorooctanoic acid and perfluorooctanesulfonic acid.

Fitz-Simon N, Fletcher T, Luster MI, Steenland K, Calafat AM, Kato K, Armstrong B.
Epidemiology. 2013 Jul;24(4):569-76.
Full text available at: http://journals.lww.com/epidem/Abstract/2013/07000/Reductions_in_Serum_Lipids_with_a_4_year_Decline.13.aspx

Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans.

Fletcher T, Galloway TS, Melzer D, Holcroft P, Cipelli R, Pilling LC, Mondal D, Luster M, Harries LW.
Environ Int. 2013 Jul;57-58:2-10.
Full text available at: http://dx.doi.org/10.1016/j.envint.2013.03.008

Perfluorooctanoate and neuropsychological outcomes in children.

Stein CR, Savitz DA, Bellinger DC.
Epidemiology. 2013 Jul;24(4):590-9.
Full text available at: http://journals.lww.com/epidem/Abstract/2013/07000/Perfluorooctanoate_and_Neuropsychological_Outcomes.17.aspx

Serum perfluoroalkyl acids concentrations and memory impairment in a large cross-sectional study.

Gallo V, Leonardi G, Brayne C, Armstrong B, Fletcher T.
BMJ Open. 2013 Jun 20;3(6).
Full text available at: http://bmjopen.bmj.com/content/3/6/e002414.long

Exposure to perfluoroalkyl acids and markers of kidney function among children and adolescents living near a chemical plant.

Watkins DJ, Josson J, Elston B, Bartell SM, Shin HM, Vieira VM, Savitz DA, Fletcher T, Wellenius GA.
Environ Health Perspect. 2013 May;121(5):625-30.
Full text available at: http://ehp.niehs.nih.gov/1205838/

Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: a geographic analysis.

Vieira VM, Hoffman K, Shin HM, Weinberg JM, Webster TF, Fletcher T.
Environ Health Perspect. 2013 Mar;121(3):318-23.
Full text available at: http://ehp.niehs.nih.gov/1205829/

Cohort mortality study of workers exposed to perfluorooctanoic acid.

Steenland K, Woskie S.
Am J Epidemiol. 2012 Nov;176(10):909-17.
Full text available at: http://aje.oxfordjournals.org/content/176/10/909.abstract

Retrospective exposure assessment of perfluorooctanoic acid serum concentrations at a fluoropolymer manufacturing plant.

Woskie SR, Gore R, Steenland K.
Ann Occup Hyg. 2012 Nov;56(9):1025-37.
Full text available at: http://annhyg.oxfordjournals.org/content/56/9/1025.abstract

Modeling the air-soil transport pathway of perfluorooctanoic acid in the Mid-Ohio Valley using linked air dispersion and vadose zone models

Shin HM, Ryan PB, Vieira VM, Bartell SM.
Atmospheric Environment. 2012 May;51:67-74.
Full text available at: http://www.sciencedirect.com/science/article/pii/S1352231012000702

Perfluorooctanoic Acid exposure and pregnancy outcome in a highly exposed community

Savitz DA, Stein CR, Bartell SM, Elston B, Gong J, Shin H-M, Wellenius GA.
Epidemiology. 2012 May;23(3):386-92.
doi: 10.1097/EDE.0b013e31824cb93b
Full text available at: http://dx.doi.org/doi:10.1097/EDE.0b013e31824cb93b

Thyroid Function and Perfluoroalkyl Acids in Children Living Near a Chemical Plant

Lopez-Espinosa M-J, Mondal D, Armstrong B, Bloom MS, Fletcher T.
Environ Health Perspect. 2012 Mar 27. [Epub ahead of print]
doi: 10.1289/ehp.1104370
Full text available at: http://dx.doi.org/10.1289/ehp.1104370

Relationship of Perfluorooctanoic Acid Exposure to Pregnancy Outcome Based on Birth Records in the Mid-Ohio Valley

Savitz DA, Stein CR, Elston B, Wellenius GA, Bartell SM, Shin H-M, Vieira VM, Fletcher T.
Environ Health Perspect. 2012 Mar 26. [Epub ahead of print]
doi: 10.1289/ehp.1104752
Full text available at: http://dx.doi.org/doi:10.1289/ehp.1104752

Modeling the air-soil transport pathway of perfluorooctanoic acid in the mid-Ohio Valley using linked air dispersion and vadose zone models

Shin H-M, Ryan PB, Vieira VM, Bartell SM.
Atmospheric Environ. 2012 May; 51:67-74. Epub 2012 Feb 1.
doi: 10.1016/j.atmosenv.2012.01.049
Full text available at: http://dx.doi.org/doi:10.1016/j.atmosenv.2012.01.049

Serum Perfluorooctanoate (PFOA) and Perfluorooctane Sulfonate (PFOS) Concentrations and Liver Function Biomarkers in a Population with Elevated PFOA Exposure

Gallo V, Leonardi G, Genser B, Lopez-Espinosa M-J, Frisbee SJ, Karlsson L, Ducatman AM, Fletcher T.
Environ Health Perspect. 2012 May;120(5):655-660. Epub 2012 Jan 30.
doi: 10.1289/ehp.1104436
Full text available at: http://dx.doi.org/doi:10.1289/ehp.1104436

Relationships of Perfluorooctanoate and Perfluorooctane Sulfonate Serum Concentrations Between Child-Mother Pairs in a Population with Perfluorooctanoate Exposure from Drinking Water

Mondal D, Lopez-Espinosa M-J, Armstrong B, Stein CR, Fletcher T.
Environ Health Perspect. 2012 May;120(5):752-757. Epub 2012 Jan 23.
doi: 10.1289/ehp.1104538
Full text available at: http://dx.doi.org/doi:10.1289/ehp.1104538

Retrospective exposure estimation and predicted versus observed serum perfluorooctanoic acid concentrations for participants in the C8 Health Project

Shin H-M, Vieira VM, Ryan PB, Steenland K, Bartell SM.
Environ Health Perspect. 2011 Dec;119(12):1760-1765. Epub 2011 Aug 3.
doi: 10.1289/ehp.1103729
Full text available at: http://dx.doi.org/doi:10.1289/ehp.1103729

Serum Perfluorinated Compound Concentration and Attention Deficit/Hyperactivity Disorder in Children 5–18 Years of Age

Stein CR, Savitz DA.
Environ Health Perspect. 2011 Oct;119(10):1466-1471. Epub 2011 Jun 10.
doi: 10.1289/ehp.1003538
Full text available at: http://dx.doi.org/doi:10.1289/ehp.1003538

Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with age of puberty among children living near a chemical plant.

Lopez-Espinosa M-J, Fletcher T, Armstrong B, Genser B, Dhatariya K, Mondal D, Ducatman A, Leonardi G.
Environ Sci Technol. 2011 Oct 1;45(19):8160-6. Epub 2011 May 2.
doi: 10.1021/ es1038694
Full text available at: http://pubs.acs.org/doi/abs/10.1021/es1038694

Comparison between free serum thyroxine levels, measured by analog and dialysis methods, in the presence of perfluorooctane sulfonate and perfluorooctanoate.

Lopez-Espinosa M-J, Fitz-Simon N, Bloom MS, Calafat AM, Fletcher T.
Reprod Toxicol. 2012 July;33(4):552-555. Epub 2011 Apr 17.
doi: 10.1016/j.reprotox.2011.04.002
Full text available at: http://dx.doi.org/doi:10.1016/j.reprotox.2011.04.002

Environmental fate and transport modeling for perfluorooctanoic acid emitted from the Washington Works Facility in West Virginia.

Shin H-M, Vieira VM, Ryan PB, Detwiler R, Sanders B, Steenland K, Bartell SM.
Environ Sci Technol. 2011 Feb;45(4):1435-1442. Epub 2011 Jan 12.
doi: 10.1021/es102769t
Full text available at: http://pubs.acs.org/doi/abs/10.1021/es102769t

Private drinking water wells as a source of exposure to PFOA in communities surrounding a fluoropolymer production facility.

Hoffman K, Webster TF, Bartell SM, Weisskopf MG, Fletcher T, Vieira VM.
Environ Health Perspect. 2011 Jan;119(1):92-7. Epub 2010 Oct 4.
doi: 10.1289/ehp.1002503
Full text available at: http://dx.doi.org/10.1289/ehp.1002503

Accumulation and clearance of PFOA in current and former residents of an exposed community.

Seals R, Bartell SM, Steenland K.
Environ Health Perspect. 2011 Jan;119(1):119-24. Epub 2010 Sep 22.
doi: 10.1289/ehp.1002346
Full text available at: http://dx.doi.org/10.1289/ehp.1002346

Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: Results from the C8 Health Project.

Frisbee SJ, Shankar A, Knox SS, Steenland K, Savitz DA, Fletcher T, Ducatman AM.
Arch Pediatr Adolesc Med. 2010 Sep;164(9):860-9.
doi: 10.1001/archpediatrics.2010.163
Full text available at: http://archpedi.ama-assn.org/cgi/content/short/164/9/860

Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA).

Steenland K, Fletcher T, Savitz DA.
Environ Health Perspect. 2010 Aug;118(8):1100-8. Epub 2010 Apr 27.
doi: 10.1289/ehp.0901827
Full text available at: http://dx.doi.org/10.1289/ehp.0901827

Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with uric acid among adults with elevated community exposure to PFOA.

Steenland K, Tinker S, Shankar A, Ducatman A.
Environ Health Perspect. 2010 Feb;118(2)229-33.
doi: 10.1289/ehp.0900940
Full text available at: http://dx.doi.org/doi:10.1289/ehp.0900940

Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia.

Bartell SM, Calafat AM, Lyu C, Kato K, Ryan PB, Steenland K.
Environ Health Perspect. 2010 Feb;118(2):222-8.
doi: 10.1289/ehp.0901252
Full text available at: http://dx.doi.org/doi:10.1289/ehp.0901252

The C8 Health Project: Design, methods, and participants.

Frisbee SJ, Brooks AP Jr, Maher A, Flensborg P, Arnold S, Fletcher T, Steenland K, Shankar A, Knox SS, Pollard C, Halverson JA, Vieira VM, Jin C, Leyden KM, Ducatman AM.
Environ Health Perspect. 2009 Dec;117(12):1873-1882. Epub 2009 Jul 13.
doi: 10.1289/ehp.0800379
Full text available at: http://dx.doi.org/10.1289/ehp.0800379

A cross-sectional analysis of type II diabetes in a community with exposure to perfluorooctanoic acid (PFOA).

MacNeil J, Steenland NK, Shankar A, Ducatman A.
Environ Res. 2009 Nov; 109(8):997-1003. Epub 2009 Sep 8.
doi: 10.1016/j.envres.2009.08.002
Full text available at: http://dx.doi.org/10.1016/j.envres.2009.08.002

Association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults living near a chemical plant.

Steenland K, Tinker S, Frisbee S, Ducatman A, Vaccarino V.
Am J Epidemiol. 2009 Nov 15;170(10):1268-78. Epub 2009 Oct 21.
doi: 10.1093/aje/kwp279
Full text available at: http://aje.oxfordjournals.org/cgi/content/abstract/kwp279

Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome.

Stein CR, Savitz DA, Dougan M.
Am J Epidemiol. 2009 Oct 1;170(7):837-846. Epub 2009 Aug 19.
doi: 10.1093/aje/kwp212
Full text available at: http://aje.oxfordjournals.org/cgi/content/abstract/170/7/837

Predictors of PFOA levels in a community surrounding a chemical plant.

Steenland K, Jin C, MacNeil J, Lally C, Ducatman A, Vieira V, Fletcher T.
Environ Health Perspect. 2009 Jul;117(7):1083-1088. Epub 2009 Mar 23.
doi: 10.1289/ehp.0800294
Full text available at: http://dx.doi.org/doi:10.1289/ehp.0800294

Note on accessing the full articles: for some of the above articles only the abstract is available online. This means that a photocopy or an online pdf document version of the full text of the article can only be obtained from the authors, from someone who has (or a library which has) subscribed to the journal, or by paying online to the journal.